Carbamazepine에 의한 DRESS Syndrome 1예

DRESS (Drug rash with eosinophilia and systemic symptoms) syndrome is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine and phenobarbital. It is characterized by hematologic abnormalities, especially eosinophilia and mononucleosis- like atypical lymphocytosis, skin rash, fever, lymph node enlargement and single or multiple organ involvement, which starts within 8 weeks of the initiation of therapy. Despite these characteristic findings, generally clinicians have difficulty finding out culprit drugs. Herein, we report a case of carbamazepine-induced DRESS syndrome which developed erythematous skin eruptions 8 weeks after carbamazepine therapy. (Korean J Asthma Allergy Clin Immunol 2011; 31:59-62)