The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression

Abstract Purpose Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori ( H. pylori ) affects the gastric expression of growth factors and serum gastrin concentrations. Patients/methods We examined immunohistochemically gastric EGF and both receptors’ expression in: gastric cancer (GC; n  = 29), chronic gastritis with H. pylori infection (GHp+; n  = 40) before and after eradication and in patients without H. pylori infection (GHp−; n  = 42). Results Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp− ( p p Conclusions In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.