Clinical research of treatment about childhood patient with chronic sinusitis based on the "European Position Paper on rhinosinusitis and nasal polyps 2007"

Objective To explore the clinical application of treatment on childhood patient with chronic sinu-sitis (CRS) based on "European Position Paper on rhinosinusitis and nasal polyps 2007" (EPOS 2007) under the background of real world research. Methods A multi-center prospective crossover study was performed, and 60 cases of CRS diagnosed base on clinical features and CT imaging who were applied of small doses of azithromycin and montelukast for 12 weeks or more were selected.Nineteen cases prolonged azithromycin and /or montelukast treatment, and 9 cases of them were added a short course (5-7 days) of cefaclor and 3 cases of them added loratadine and nasal corticosteroids.Visual analog scale(VAS) was used for subjective evaluation and Lund-Mackay CT was used for objective evaluation after 12 weeks of treatment. Results After 12 weeks of treatment, the average VAS score was decreased from (7.92±2.66) to (2.13±1.11), and there was a significant difference(t=4.01, P=0.001); Lund-Mackay CT score was decreased from (14.12±3.30) to (2.53±1.71), and there was significant difference(t=2.83, P=0.005). Forty-one cases were followed up for (18.12±6.25 )months after 12 weeks treatment, and the drug withdrawal showed no recurrence of CRS symptoms.The other 19 cases were received with azithromycin and/or montelukast treatment longer or combined with a short course of cefaclor, or nasal corticosteroids respectively, and were followed up for (6.23±2.13) months after extend to 24 weeks of total course could withdrawal, and there was no recurrence of CRS symptoms after drug withdrawal. Conclusions There is a significant effect after application of azithromycin and montelukast on treatment of CRS base on EPOS 2007. Key words: Sinusitis, chronic; Treatment; Real world research; Child