In vitro susceptibility of Plasmodium falciparum tomonodesethylamodiaquine, quinine, mefloquine and halofantrine inAbidjan (Côte d'Ivoire)
2010
Background: Malaria is the primary cause of hospitalization in
Cτte d′Ivoire. Early treatment is one of the strategies to
control this illness. However, the spread of resistance of Plasmodium
falciparum to antimalarial drugs can seriously compromise this
strategy. Objectives: The aim of this study was to assess the in vitro
susceptibility of P. falciparum to monodesethylamodiaquine and
aminoalcohols in Abidjan (Cτte d′Ivoire). Methods: We
assessed the in vitro susceptibility of isolates collected from
patients with uncomplicated malaria by using the WHO optical microtest
technique. Results: The proportions of resistance to
monodesethylamodiaquine, mιfloquine and halofantrine were 12.5%,
15.6% and 25.9%, respectively. For quinine, none of isolates showed
evidence of in vitro resistance. However, two isolates (6.1%) had IC 50
values above 300 nM. The IC 50 of each drug was positively and
significantly correlated to that of the other three drugs, and the
correlation was higher between halofantrine and mefloquine.
Conclusions: Our results showed that the in vitro chloroquine
resistance reported in previous studies has been extended to other
antimalarial drugs investigated in this study except for quinine.
Therefore, it is necessary to implement a long-term monitoring system
of antimalarial drug resistance.
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