Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab
2017
Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab
(BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer
aqueous dispersions were used since this system is able to maintain their fluidity at low temperatures
( 35oC). In the present study we aimed at evaluating
the effect of Poloxamer to prolong the effect of SUM.
These formulations were characterized using rheological, biopharmaceutical (drug release) and morphological
(SEM) technique. Corneal NV was induced in Sprague Dawley rats Corneal. At 15 days of follow up animals
were sacrificed and perfused with black drawing ink. Digital photographs were taken and the area of neovascularisation
(ANV) was calculated using the image programmed. The rheological behavior was influenced by the
addition of drugs, resulting in a decrease in the gelation temperature (T sol/gel ). Both drugs were released from
poloxamer gels by means of an anomalous mechanism. However, BVM was released faster than SUR, with their
combination (SUM) to appearing to reduce delivery, probably due to interactions between the drugs or with the
polymeric matrix. The in vivo studies showed that SUM-poloxamer gel was able to increase the corneal antiangiogenic
effect compared to the SUM solution and BVM alone at 15 days of follow-up. Furthermore no injurious
effects were observed in the histological tissue examination after drug administration. The presence of Poloxamer,
known to modulate control release of biological agents, seems to have a favorable effect on SUM subconjunctival
administered.
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