Absence of linkage to 8q23.3-q24.1 and 2p11.1-q12.2 in a new BAFME pedigree in China: Indication of a third locus for BAFME

Abstract Benign adult familial myoclonic epilepsy (BAFME) were mapped on chromosome 8q24 and 8q23.3–q24.1 in Japanese pedigrees and mapped on 2p11.1–2q12.2 in European pedigrees, respectively. Recently, we recruited a large BAFME pedigree in China. After genotyping 11 microsatellite markers covering the two previously identified chromosome regions, we performed linkage analyses. However, evidence of negative linkage was found in the two previously reported candidate regions (LOD score