RDNA-13. VALIDATION OF BEHAVIORAL ANALYSIS ACROSS AGE IN A MOUSE MODEL FOR FUTURE INVESTIGATION OF RADIATION-INDUCED HYPERSOMNOLENCE (RIH) IN PRIMARY BRAIN TUMOR (PBT) PATIENTS

BACKGROUND Cranial radiation is part of standard PBT treatment with patient age recognized to impact response and toxicity. RIH is one of the most common toxicities. We have reported an association between circadian gene variants and RIH susceptibility. No rodent model for RIH has been validated. The purpose of this study is to evaluate the impact of age on activity and circadian behavior to inform our novel mouse model of RIH.