Routine production of 2-deoxy-2-[18F]fluoro-d-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

Abstract Resin-supported [ 18 F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [ 18 F]FDG. “No-carrier-added” [ 18 F]fluoride ion is collected on a quaternary 4-( N , N -dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [ 18 O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra- O -acetyl-2- O -trifluoromethanesulfonyl-β- d -mannopyrannose. Acidic hydrolysis yields [ 18 F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.