Interleukin-1α released from HSV-1-infected keratinocytes acts as a functional alarmin in the skin

HSV-1 is known to evade the immune system by retention of interleukin-1β. Here, the authors show that HSV-1-infected keratinocytes circumvent this mechanism by release of interleukin-1α, which recruits leukocytes and prevents viral dissemination.