Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine

Danielle L. Taylor,Arun K. Tiwari,Jeffrey A. Lieberman,Steven Potkin,Herbert Y. Meltzer,Joanne Knight,Gary Remington,Daniel Müller,James L. Kennedy

Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine

2016

Danielle L. Taylor
Arun K. Tiwari
Jeffrey A. Lieberman
Steven Potkin
Herbert Y. Meltzer
Joanne Knight
Gary Remington
Daniel Müller
James L. Kennedy

Altered glutamate neurotransmission is implicated in the etiology of schizophrenia (SCZ) and the pharmacogenetics of response to clozapine (CLZ), which is the drug of choice for treatment-resistant SC

Keywords:

Drug
Pharmacogenetics
Etiology
Neurotransmission
Glutamate receptor
Gene
Pharmacology
Schizophrenia
Medicine
Clozapine
GRIA1
SLC1A2
Schizoaffective disorder
Antipsychotic
Brief Psychiatric Rating Scale

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