Clinical analysis of cathetei-related bloodstream infection

Objective To study the incidence and pathogenic etiology of catheter-related bloodstream infection (CRBSI) in intensive care unit (ICU) and general ward, and to provide basis for the prevention and therapy of CRBSI. Methods 131 cases of CRBSI were divided into ICU group and general ward group. The clinical data, pathogens, catheter location, and prognosis were analyzed retrospectively. Results There was no statistical significance on age and gender between ICU group (88 cases) and general ward group (43 cases) ( P ＞0. 05). APACHE Ⅱ score in ICU group was higher than that in general ward group ( P =0.039). The incidence of CRBSI in the femoral vein was the highest. There were 152 pathogenic strains isolated from the two groups. There were 106 strains in ICU group, in which 43 strains (40.6%) were gram-positive cocci, 41 strains (38.7%) were gram-negative bacilli, and 22 strains (20. 7%) were fungi. There were 46 strains in general ward group, in which 29 strains (63. 0%) were gram-positive cocci, 13 strains (28. 3%) were gram-negative bacilli, and four strains (8. 7%) were fungi. 16 patients (18. 2%) and four patients (9. 3%) respectively died due to CRBSI in ICU group and general ward group ( P ＞0. 05). The mortality in patients with mixed infection was significantly higher than that in patients with single-strain infection ( P =0.004). The top three pathogens associated with death were fungi (12 strains), Enterococcus (six strains), and Pseudomonas aeruginosa (three strains). Conclusions The pathogenic strains of CRBSI were different between ICU and general ward, which may be of clinical significance in antibiotic therapy and prognosis. Key words: Catheter-related bloodstream infection ;  Intensive care unit;  General ward