Synthetic method for preparing pyraclostrobin intermediate from o-nitrobenzyl chloride
2016
The invention discloses a synthetic method for preparing a pyraclostrobin intermediate from o-nitrobenzyl chloride. The synthetic method includes the following steps that a catalyst is added into o-nitrotoluene, heating and stirring are carried out, chlorine is slowly introduced, o-nitrotoluene is recycled after the reaction is finished, and o-nitrobenzyl chloride is obtained; o-nitrobenzyl chloride and 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole are subjected to an etherification reaction, and 2-[(N-4-chlorphenyl)-3-pyrazolyloxymethyl]nitrobenzene is obtained. According to the synthetic method, o-nitrobenzyl chloride is substituted for o-nitrobenzyl bromide to react with 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole, the pyraclostrobin intermediate 2-[(N-4-chlorphenyl)-3-pyrazolyloxymethyl]nitrobenzene is obtained, the defects of an existing synthetic method using o-nitrobenzyl bromide are overcome, and the etherification product with the content larger than or equal to 98% and the yield larger than or equal to 90% can be prepared.
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