Study on the expression of TGF-β_1 in rats model with irritable bowel syndrome

Objective: To observe the expression of transforming growth factor-β1 in rats model with irritable bowel syndrome and investigate the effect of TGF-β1on antiinflammatory cytokine.Methods:Rats model of IBS by intracolonic instillation of acid and restraint stess and single restraint stess methords,while the positive and control group were designed,after the visceral sensitivity was detected in the rats of each group,the expression of TGF-β1was detected by immunohistochemistry.Results:The contraction frequency of the abdominal muscle in two rat model groups was significantly enhanced as compared with two control groups(P0.05～0.01).There were no signs of inflammation in the rats of each group.The expression of TGF-β1different position of each group was no significant difference(P0.05).Conclusions: TGF-β1 may be an important regulatory factor in IBS which acts as a antiinflammatory cytokine by indirect means.