Molecular characterization and immune modulation properties of Clonorchis sinensis -derived RNASET2

Background Clonorchis sinensis (C. sinensis, Cs) is a trematode parasite that often causes chronic cumulative infections in the hepatobiliary ducts of the host and can lead to pathological changes by continuously released excretory/secretory proteins (ESPs). A T2 ribonuclease in trematode ESPs, has been identified as a potent regulator of dendritic cell (DCs) modulation. We wondered whether there was a counterpart present in Cs ESPs with similar activity. To gain a better understanding of Cs ESPs associated immune responses, we identified and characterized RNASET2 of C. sinensis (Cs RNASET2) in this paper.