Palladium(0)-Catalyzed IntramolecularHeck Reaction: A Resourceful Route for the Synthesis of Naphthoxepineand Naphthoxocine Derivatives

The synthesis of oxocines and oxepines is difficult. Two efficient protocols have been developed for the construction of naphthoxepine and naphthoxocine derivatives by sequential Wittig olefination and intramolecular Heck reaction.