The influence of dimethyl sulfoxide on resin–dentin bonding: A systematic review

Abstract Objective This article aims to systematically review published literature about the influence of dimethyl sulfoxide (DMSO) on resin–dentin bonding. Materials and methods Online databases (Medline (PubMed), Embase, Web of Science, and the Cochrane Library) were searched on this topic. Gray literature was searched using Google Scholar. Published works until December 2020 were collected, and pertinent articles were selected in accordance with the eligibility criteria. Quality assessment was conducted via the modified Consolidated Standards of Reporting Trials (CONSORT) checklist and the modified Cochrane risk of bias tool. Results Thirty-eight studies were identified, twelve of which satisfied the eligibility criteria were included in this review. Micro tensile bond strength (MTBS) was set as the main outcome. Secondary outcomes include nanoleakage evaluation, the effect of DMSO on dentin collagen fibrils, and protease inhibition. Several studies proved the promotion of DMSO on long-term dentin bond strength of etch-and-rinse adhesives. However, evidence about its effect on bond strength of self-etch adhesives was insufficient. Different concentrations of DMSO solution also cause diverse impact on dentin bonds. Conclusion Based on the included studies, DMSO considerably affects resin–dentin bonds by dissociating demineralized dentin matrix, inhibiting matrix metalloproteinases (MMPs), and enhancing penetration of resin monomers. The influence of DMSO on dentin bonding may offer inspirations for dental clinical practice to optimize resin–dentin bonds.