β 2 -adrenoceptor signaling reduction is involved in the inflammatory response of fibroblast-like synoviocytes from adjuvant-induced arthritic rats

Huaxun Wu,Jingyu Chen,Chun Wang,Lihua Liu,Yujing Wu,Yunfang Zhang,Aiwu Zhou,Lingling Zhang,Wei Wei

β 2 -adrenoceptor signaling reduction is involved in the inflammatory response of fibroblast-like synoviocytes from adjuvant-induced arthritic rats

2019

Huaxun Wu
Jingyu Chen
Chun Wang
Lihua Liu
Yujing Wu
Yunfang Zhang
Aiwu Zhou
Lingling Zhang
Wei Wei

Objective To investigate the effects of β-AR signaling on fibroblast-like synoviocytes (FLS) from adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on β-AR desensitization mediated by GRK2 and β-arrestin2.

Keywords:

Biochemistry
Salbutamol
Adjuvant
Arthritis
Adrenergic receptor
Internal medicine
Fibroblast
Endocrinology
Medicine
Beta adrenergic receptor kinase
Flow cytometry
RANKL
Isoprenaline
Inflammation
Desensitization (telecommunications)
Agonist
Viability assay

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