The anti-Toxoplasma activity of ginkgolic acids,azithromycin and allicin

To evaluate the anti-Toxoplasma activities of ginkgolic acids,azithromycin and allicin,the human foreskin fibroblast(HFF) cells and KM mice were infected with Toxoplasma gondii RH strain.The MTT assay was used to determine the safe concentrations of the drugs and to evaluate the anti-T.gondii effect in vitro.The effects on anti-Toxoplasma activity of the drugs were also evaluated on counting the mean survive time of the KM mice after intraperitoneal injection.The results indicated that both ginkgolic acids and azithromycin could inhibit the growth of T.gondii in vitro,and the mean survive time of the mice were prolonged with the use of ginkgolic acids and azithromycin in vivo,however,allicin showed very weak effect on T.gondii in vitro and in vivo.It is evident that ginkgolic acids can inhibit the growth of T.gondii in vitro and in vivo.