Surface enhanced Raman micro-structural substrate and preparation method thereof

The invention discloses a surface enhanced Raman micro-structural substrate and a preparation method thereof. The surface enhanced Raman micro-structural substrate consists of a quartz microneedle array and metal nano particles on surfaces of microneedles, wherein the diameter of the bottom face of each microneedle ranges from 500 nanometers to 200 micrometers, and the diameter of the metal nano particles ranges from 10 nanometers to 1 micrometer. The preparation method includes the steps: (1) preparing the quartz microneedle array; and (2) coating a layer of metal nano particle film with the diameter ranging from 10 nanometers to 1 micrometer on the surface of the tip end of the quartz microneedle array. The surface enhanced Raman micro-structural substrate and the preparation method thereof are novel in structure and simple in preparation and can be applied to the fields of micro-nano optics, biology, sensing, information and the like.