Fabrication of S-MoSe2/NSG/Au/MIPs imprinted composites for electrochemical detection of dopamine based on synergistic effect

Abstract An imprinted electrochemical sensor based on S-MoSe2/NSG/Au composite is firstly synthesized via a novel hydrothermal route with large surface area and abundant binding cavities for synergistic effect on dopamine (DA) recognition. High sensitivity obtained can be dramatically attributed to the electrical conductivity of S-MoSe2, Au, and catalytic ability of NSG. The selectivity of the biosensor for dopamine detection in differential pulse voltammetry (DPV) measurement does correspond to the high affinity and specificity of molecularly imprinted polymers (MIPs) using polypyrrole as functional monomer, which can distinguish DA from structural analogues of ascorbic acid and uric acid. The design takes advantage of electrochemical sensor based on S-MoSe2/NSG/Au/MIPs composite, showing a wide linear dynamic range (LDR) from 0.05 μM to 1000 μM, the limit of detection (LOD) of 0.02 μM and limit of quantification (LOQ) of 0.066 μM. A series of DA concentration analyzed in human blood samples have demonstrated the potential of the developed sensor used in practical application. The present work might open a new perspective for the research in electrochemical sensor in term of novel nanomaterials.