044. Sleep apnoea syndrome after growth hormone therapy in a patient with Prader- Willi syndrome

Background Prader-Willi syndrome (PWS) is a rare genetic disorder, which incidence is 1/10,000-1/30,000. It is characterized by hypotonia, short stature, delayed motor and mental development, hypogonadism, hyperphagia, obesity and specific physical appearance. It has been observed increased frequency of obstructive apneas-hypopnoeas and sleep architecture disorder in patients with PWS. Prescription of growth hormone (GH) is indicated in childhood, in patients with genetic confirmed syndrome and growth disorders. However, several case reports raise the question of interaction between the growth hormone therapy and apnea syndrome.