Growth of Human Renal Cell Carcinoma in Nude Mice

In metastasized renal cell carcinoma successful treatment has not been established so far (McDonald 1982). Therefore, further experimental research is necessary to attack this problem. Such studies require reliable and well defined tumor models. Xenotransplantation of human renal cell carcinoma to thymusaplastic, congenital immune-deficient nude mice seems to be a useful model system provided that the human-specific characteristics are retained. Some human kidney tumors were successfully established in nude mice and accordingly characterized (Baisch et al. 1986; Clayman et al. 1985; Hohn and Schroder 1978; Otto et al. 1981; Otto et al. 1984).