Clinical efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection

Objective To investigate the efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection (ESD) and delayed bleeding. Methods A total of 9874 patients with gastrointestinal mucosal or submucosal tumors underwent ESD in our center from September 2006 to August 2013 and intractable bleeding occurred during ESD in 5 cases. Under the condition of no effective hemostasis methods, the tissue adhesive injection or spray were used to stop the bleeding. The efficacy and safety were evaluated. Results All the 5 cases were successfully managed by the hemostasis method with tissue adhesive without any adverse event. In follow-up of two months after operation, wound healing and scar formation were observed under endoscopy. Conclusion Tissue adhesive is safe, effective and fast for intractable bleeding during ESD and delayed bleeding. Key words: Tissue adhesive; Intractable bleeding; Endoscopic submucosal dissection