Increased number of negative lymph nodes is associated with improved survival outcome in node positive gastric cancer following radical gastrectomy

// Rong-liang Shi 1, 2, 3, * , Qian Chen 1, * , Jun Bing Ding 1 , Zhen Yang 1 , Gaofeng Pan 1 , Daowen Jiang 1, 4 , Weiyan Liu 1 1 Department of General Surgery, Minhang Hospital, Fudan University, Shanghai, People’s Republic of China 2 Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China 3 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China 4 Department of Thoracic Surgery, Minhang Hospital, Fudan University, Shanghai, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Daowen Jiang, e-mail: daowenjiangfudan@163.com Weiyan Liu, e-mail: weiyanliufudan@163.com Keywords: gastric cancer, negative lymph node, SEER Received: February 06, 2016      Accepted: April 15, 2016      Published: April 27, 2016 ABSTRACT The concept of negative lymph node (NLN) counts has recently attracted attention as a prognostic indicator in various cancer. However, the correlation between NLN counts and patient prognosis in the setting of gastric cancer is not fully studied. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Clinicopathological characteristics, including race, age, gender, and tumor stage, grade, and cause specific survival were collected. Univariate and multivariate Cox proportional hazards model were used to assess the risk factors for survival. As results, X-tile plots identified 3 and 9 as the optimal cutoff value to divide the patients into high, middle and low risk subsets in terms of cause specific survival, and NLN was validated as independently prognostic factor in mulivariate Cox analysis ( P < 0.001). Further analysis showed that NLN was a prognosis factor in each N stage. Collectively, our study results firmly demonstrated that the number of NLNs was an independent prognostic factor for gastric cancer patients, and together with the N stage, it could provide more accurate prognostic information than the N stage alone.