Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid.

Abstract Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b , 2a , 2b , 3a , 3b , 4a , 4b , 5 , inhibiting proliferation of distinct cancer cell types with an IC 50 in the low micromolar range.