Synthesis and Pharmaco-Toxicological Characteristics of 3-Substituted 4-Hydroxy-6-Phenyl-3,4-Dihydro-2H-1,3-Oxazines

Reactions between 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-dione and various arylidenearylamines formed 3-substituted 4-hydroxy-6-phenyl-3,4-dihydro-2H-1,3-oxazines. The synthesized compounds were examined in vitro for antioxidant properties, cytotoxic activity, and acute toxicity. The highest antioxidant activity was observed for (2Z)-3-hydroxy-3-[(4-hydroxy-2-(4-methylphenyl)-3, 6-diphenyl-3, 4-dihydro-2H-1,3-oxazin-4-yl]-1-phenylprop-2-en-1-one (IIb) and (2Z)-3-hydroxy-[4-hydroxy-3-(4-methoxyphenyl)-2-(4-methylphenyl)-6-phenyl-3,4-dihydro-2H-1,3-oxazin-4-yl]-1-phenylprop-2-en-1-one (IIc). The synthesized compounds did not exhibit cytotoxic properties in vitro.