Chronic toxicity study on a new glucan extracted from candida albicans in rats

Fifty-two-week oral toxicity of a new glucan (Glucanil®, Gluimmun®) extracted from Candida albicans ATCC 20955 was investigated in rats. The glucan was orally administered in dose levels up to 200 mg/kg/d and was well tolerated. No deviation from normality was observed in mortality, physical appearance and general behaviour of the treated animals. Food and water consumption and body weight gain of glucan-fed groups did not differ from those of control animals. In these groups no alteration of the weight of the main organs was also observed