Systems biology of metabolic and signaling networks : energy, mass and information transfer

I Introduction.- From Physiology, Genomes, Systems and Self-Organization to Systems Biology: The Historical Roots of a 21st Century Approach to Complexity.- Systems Biology of Networks: The Riddle and the Challenge.- II Systems Biology of Signaling Networks.- Micrornas and Robustness In Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic And Genetic.- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy.- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling.- The Control Analysis of Signal Transduction.- III Systems Biology of Cellular Structures and Fluxes.- Moonlighting Function of the Tubulin Cytoskeleton.- Metabolic Dissipative Structures.- Systems Biology Approaches to Cancer Energy Metabolism.- IV Systems Biology of Organ Function.- Network Dynamics in Cardiac Electrophysiology.- Systems Level Regulation of Energy Fluxes via Metabolic Cycles. Role of Creatine and Phosphotransfer Pathways.- V Systems Biology of Microorganisms.- Temporal Partitioning of the Yeast Cellular Network.- Systems Biology and Metabolic Engineering in Bacteria.