Survey of acute post-stroke infection and analysis of etiology

OBJECTIVE To investigate the incidence of acute post-stroke infection in patients with acute stroke,the distribution of infection sites,the major pathogenic bacteria and their antimicrobial susceptbility.METHODS We consecutively recruited 545 acute stroke patients admitted to the hospital(onset of≤2 weeks),the incidence and the infection sites were investigated,and the results of pathogen culture and drug susceptibility test were analyzed.RESULTS The incidence of acute post-stroke infections was 18.5%;the major infection sites were respiratory system and urinary system;the incidence of pneumonia after acute stroke was 11.0%.Of the pathogenic bacteria cultured,gram-negative bacteria accounted for 67.5%,which were mainly Escherichia coli,Klebsiella pneumoniae and Pseudomonas aeruginosa;gram-positive bacteria accounted for 25.3%,which were mainly Staphylococcus aureus isolates;fungi accounted for 7.2%.Gram-negative bacilli were mainly susceptible to imipenem,amikacin,netilmicin and tobramycin;Staphylococcus aureus was mainly susceptible to nitrofurantoin demethylvancomycin and teicoplanin;ESBLs-producing rates of E.coli and K.pneumoniae were 50.0% and 46.2%,respectively;S.aureus strains were all methicillin-resistant S.aureus(MRSA).CONCLUSION The incidence of infection after acute stroke is high.Most of the pathogenic bacteria are opportunistic pathogens among which gram-negative bacilli are the most common.