Effect of Ligustrazine Hydrochloride on Coagulation Reaction and Inflammation Reaction in Single Valve Replacement Patients with Rheumatic Heart Disease Undergoing Cardiopulmonary Bypass

Objective To observe the protection effect of Ligustrazine Hydrochloride(LH)on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass(CPB).Methods Totally 4 0 patients undergoing single valve replacement were recruited in the study and randomly assigned to the two groups,the treatment group and the control group,2 0 in each group.In treatment group LH(3 mg/kg)was intravenously infused from the jugular vein.LH(3 mg/kg)was also added in the CPB priming.In the control group LH was replaced by equal amount of normal saline.Endothelial micro-particles(EMP)count was detected before CPB,3 0 min after CPB,1 h and 2 4 h after CPB finished.The coagulation reaction time(R),coagulation time(K),clotting formation velocity(αangle),maximum amplitude(MA),coagulation index(CI),platelet(PLT),hypersensitive C reactive protein(hs-CRP),IL-6,and IL-1 0 were detected before CPB,1 h and 2 4 h after CPB finished.Results There was no statistical difference in aorta arresting time,period of CPB,post-operative drainage volume,plasma transfusion volume,post-operative respirator assistant time,and hospitalization time between the two groups(P0.0 5).Compared with pre-CPB in the same group,the count of EMP was much higher at 3 0 min after CPB and 1 h after CPB finished(P0.0 1).R and K,hs-CRP,IL-6,and IL-1 0 increased at 1 h and 2 4 h after CPB finished(P0.0 1,P0.0 5).Theαangle,MA,CI,and PLT decreased 1 h after CPB finished(P0.0 1).Theαangle increased,while CI and PLT decreased2 4 h after CPB finished(P0.0 5).Compared with the control group in the same period,the count of EMP was lower in the treatment group 3 0 min after CPB and 1 h after CPB finished(P0.0 5,P0.0 1).R and K values obviously decreased in treatment group 1 hour after CPB finished(P0.0 5),whileαangle,MA,CI,and PLT increased(P0.0 5,P0.0 1).hs-CRP and IL-6 decreased in the treatment group 1 h and 2 4 h after CPB finished(P0.0 5),while IL-1 0 increased(P0.0 5).The count of PLT increased 2 4 h after CPB finished in the treatment group(P0.0 5).Conclusion LH had certain protection effect on the vascular endothelium undergoing CPB,and lower excessive activation of coagulation reaction and inflammation reaction in patients undergoing CPB.