Phencyclidine (PCP) - Structure Versus Reactivity

AbstractSeventeen different compounds having structural similarities to PCP (phencyclidine) were analyzed by radioimmunoassay (RIA) using 251-phencyclidine reagents (Roche). Affinities were compared with molecular structures and several observations were made. It was found that the three-ring structure (1-phenylcyclo-hexylpiperidine) is essential for reactivity. Changes in and to the cyclohexyl ring and/or the piperidine ring reduced reactivity, while changes in the phenyl ring increased reactivity.