Antifungal steroidal lactones from Withania coagulance

Abstract Two new withanolides, 14,15β-epoxywithanolide I [(20 S ,22 R ) 17 β ,20 β -dihydroxy-14 β ,15 β -epoxy-1-oxo-witha-3,5,24-trienolide] and 17β-hydroxywithanolide K (20 S ,22 R ) 14 α ,17 β ,20 β -trihydroxy-1-oxo-witha-2,5,24-trien-olide] have been isolated from the whole plant of Withania coagulance and their structures were elucidated by spectroscopic techniques. The latter compound was found to be active against a number of potentially pathogenic fungi.