Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

In the present study, we confirm that spermidine increases [ 3 H]TCP binding (in the presence of glutamate) to well washed rat brain membranes, and show that this effect is potently antagonised by ifenprodil and SL 82.0715 at concentrations that themselves have no effect on [ 3 H]TCP binding in the absence of spermidine