Peripferal Nerve Regeneration in Response to Synthesized Nanofiber Scaffold Hydrogel

1,* nghuidrch@163.com me ; Abstract: Background: earlier studies have demonstrated that Peptide RADA16-I (AcN-RADARADARADARADA-CONH2 ) could repair spinal cord injury and optical pathway and restore visual function. The objective of the research is to investigate the role of RADA16-I in the regeneration of peripheral nerve injury in rats. Method: sciatic nerve injury was performed at female Sprague-Dawley rats. Two groups were conducted: crush group and sever group. There were RADA16-I treatment and blank control in each group. Sense Nerve Conduction (SNCV) parameters were EVALUATED on day 30 in the injured sciatic nerve by means of electrophysiological recording. The results indicates that SNCV in test groups shows a faster healing rate than blank control. Conclusion: self-assembling peptide plays a effective role in the regeneration of sciatic nerve in rats.