Motor Neurone Disease: Ethics, Outcome Variables and Clinical Scales
2001
Clinical trials in motor neurone disease (MND; USA: amyotrophic lateral sclerosis, ALS) present challenging ethical and methodological problems and practical difficulties in their implementation. Some of these are shared with other neurological disorders and others are more disease-specific. The fatal progressive course over a median of 2–3 years and the patchy, incapacitating and variable clinical expression are major features of the disorder.
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