Evaluation of the long-term prognosis of coronary heart disease with myocardial perfusion imaging: a Meta-analysis

Objective To analyze multiple functional parameters of radionuclide MPI (SRS, SSS, SDS and LVEF) in order to evaluate the long-term prognosis in patients with coronary heart disease (CHD). Methods The published articles on MPI for long-term prognosis in patients with CHD were searched in Medline, the Excerpta Medica Database (EMbase), Cochrane and China National Knowledge Infrastructure (CNKI), Wangfang Database, Vip Database from January 2003 to January 2015 with inclusion and exclusion criteria. The meta-analysis was conducted using RevMan 5.3 software. Stata 12.0 software was used to draw the funnel plot and to determine the possibility of publication bias by Begg′s test. Results A total of 11 studies and 11 634 patients were ultimately included. The meta-analysis indicated that the SRS(hazard ratio (HR)=1.14, 95% CI: 1.11-1.18; z=8.53, P<0.01), SSS(HR=1.05, 95% CI: 1.05-1.23; z=2.34, P=0.02), SDS(HR=1.14, 95% CI: 1.01-1.10; z=3.07, P=0.002) and LVEF (HR=0.95, 95% CI: 0.93-0.97; z=4.53, P<0.01) had statistical significance for the prognosis of CHD. Conclusion MPI functional parameters are significantly valuable for the evaluation of long-term prognosis in patients with CHD. Key words: Coronary disease; Prognosis; Tomography, emission-computed, single-photon; Meta-analysis