Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties

Statins are group of hypolipidemic agents that are effective at lowering blood lipid levels subsequently improving ischemia associated pathology of atherosclerosis. This beneficial effect jointly linked to the members of statin and the miscellaneous effects they produce which is distinctly present with some statins but not others. These lipid lowering agents differ structurally and physically resulting in two group based on their hydrophobicity. Since, lipophilic penetrate readily across cell membrane, hydrophilic potentially needs a carrier and their volume of distribution is lower comparative to lipophilic statins. These structural and physicochemical variation ultimately result in variation in pharmacokinetic properties and could potentially carry an impact on their pharmacodynamics and the outcome of the therapeutic course. Moreover, variation in these properties could lead to repurposing of statin for new indications in the future