Abstract 12968: mitoTEMPO Improves Expression of Pulmonary Artery Soluble Guanylate Cyclase β1 and Lowers Exercise Associated Elevations in Pulmonary Artery Pressures in a Rat Model of Combined Pre- and Post-Capillary Pulmonary Hypertension

Georgios Triantafyllou,Taijyu Satoh,Charles F. McTiernan,Sruti Shiva,Adam C. Straub,Mark T. Gladwin

Abstract 12968: mitoTEMPO Improves Expression of Pulmonary Artery Soluble Guanylate Cyclase β1 and Lowers Exercise Associated Elevations in Pulmonary Artery Pressures in a Rat Model of Combined Pre- and Post-Capillary Pulmonary Hypertension

2021

Georgios Triantafyllou
Taijyu Satoh
Charles F. McTiernan
Sruti Shiva
Adam C. Straub
Mark T. Gladwin

Introduction: Exercise induced pulmonary hypertension (EIPH) portends worse prognosis compared to isolated resting PH. Exercise increases mitochondrial reactive oxygen species (mROS) production in ...

Keywords:

Pulmonary artery
rat model
Internal medicine
Antioxidant
Pulmonary hypertension
Endocrinology
Reactive oxygen species
pre and post
smooth muscle
Medicine
Guanylate cyclase

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