Aktywność fizyczna oraz "trening mitochondriów" w stwardnieniu zanikowym bocznym (ALS)

The role of physical activity in the etiology of amyotrophic lateral sclerosis (ALS) raises a lot of controversy. Therefore, a therapy based on exercise training in people diagnosed with ALS seems to be a challenge and requires evidence confirming its effectiveness. The aim of this work is to show the potential possibilities of health training to improve the quality of life in patients with ALS, as well as to present the mechanisms through which this training works. The effectiveness of exercise in patients mainly relates to maintaining the functions of the muscles and the entire body. Much more data come from studies using animal models of ALS. It has been proven that the most effective swim training significantly extends the life of animals, delays the onset of the first symptoms of the disease, reduces weight loss and muscle degradation. It also significantly improves the metabolism of mitochondria, probably by modification of the contact sites of the mitochondrial membrane structures and the endoplasmic reticulum, and reducing oxidative stress. It seems that the current and future research results on this topic may help to develop a new way in rehabilitation activities in patients with ALS.