Mucin 4 (MUC4) antibodies to glycopeptides and their applications

The present invention, the antibody with MUC4 specificity having a sugar chain structure highly expressed in cancer cells, the glycopeptide comprising an antigen suitable for this antibody production, as well as new preventive and / or treatment and diagnosis of cancer by the antibodies providing a means and methods. The present invention relates to a monoclonal antibody against a glycopeptide. Glycopeptide consists tandem unit peptide and O- linked sugar chain of human MUC4 having the amino acid sequence shown in SEQ ID NO: 1. O- linked sugar chain is N- acetylgalactosamine (GalNAc), binds to threonine is 8 amino acid of the tandem units peptide. The invention glycopeptides for use in the production of anti-human MUC4 monoclonal antibodies, a method of detecting the MUC4 in human body fluid sample, the kit comprising the monoclonal antibody, comprising the above monoclonal antibody as an active ingredient, a malignancy prevention and / or further encompasses a pharmaceutical composition for the treatment.