Regression of left ventricular hypertrophy after treatment of hypertension: Comparison of directed M-echocardiography with magnetic resonance imaging in quantification of serial mass changes

Abstract Background: This study sought to validate the reliability of serial echocardiographic measurements in detecting left ventricular (LV) hypertrophy regression by using magnetic resonance imaging (MRI) as a reference standard. Methods and Results: We studied a small population (n = 20) of patients enrolled in the Prospective Randomized Enalapril Study Evaluating Regression of Ventricular Enlargement (PRESERVE) trial for evaluating LV hypertrophy regression. LV mass was measured by both echocardiography and MRI at baseline and after 1 year. As compared with baseline, systolic and diastolic blood pressures were significantly decreased after 1 year (all P P =.005) and by 37.1 g after 1 year ( P P P P =.02), and there were similarly wide limits of agreement for change in LV mass (±24.2 g). Conclusions: Despite the use of careful methodology, echocardiographic measurement of LV mass at a single time point or for serial studies resulted in significant variation in LV mass estimates from measurement using MRI.