Inhibition of Lycium barbarum polysaccharide on transplanted liver cancer in mice

Objective To explore the inhibition of Lycium barbarum polysaccharide(LBP) on transplanted liver cancer in mice.Methods The transplanted liver cancer model was established with hypodermic inoculation.Ninety-six mice were randomly divided into six groups: control group,model group,LBP high-,middle-,and low-dose(20,10,and 5 mg/kg) groups,and cyclophosphamide(20 mg/kg) group.The effects of LBP on mortality,gross tumor volume,inhibitory rate of tumor growth,tumorous cellular density,karyokinesis,degree of tumor necrosis,lymphocyte infiltration,and fibroplasia in interstitial substance in tumor-bearing mice were observed.Results LBP with high,middle,and low doses could obviously depress the death rate of tumor-bearing mice(P 0.05) and diminish gross tumor volume and weight(P 0.05).The inhibitory rates of tumor growth were 42.23%,25.10%,and 9.16%.LBP with high and middle doses could degrade the tumorous cellular density(P 0.05),decrease the karyokinesis(P 0.05),and increase the degree of tumor necrosis,lymphocyte infiltration,and fibroplasia in interstitial substance in mice(P 0.05).Conclusion LBP could produce the inhibition on transplanted liver cancer in mice.