Clinical features of 153 patients with COVID-19 in Chongqing municipality

Objective To analyze the clinical features of patients with COVID-19 in Chongqing Municipality. Methods The clinical data, laboratory tests and chest imaging findings of 153 patients COVID-19 admitted in Chongqing Public Health Medical Center from January 26 to February 5, 2020 were retrospectively reviewed. According to the relevant diagnostic criteria, patients were divided into non-severe group (n=132) and severe group (n=21). The correlation between serum index changes and disease severity was analyzed. Results The proportion of patients with underlying diabetes or chronic respiratory diseases in severe group was significantly higher than that in non-severe group (χ2=11.04 and 6.94, P<0.05). The proportion of symptom-free patients in non-severe group was significantly higher than that in severe group (χ2=4.09, P<0.05). The symptoms of fever, fatigue and muscle soreness in the severe group were more common than those in the non-severe group (χ2=4.40, 14.42 and 22.67, P<0.05). Among the concomitant symptoms, the proportion of cough and shortness of breath in the severe group was higher than that in the non-severe group (χ2=8.46 and 4.80, P<0.05). C-reactive protein and D-Dimer levels were higher in the severe group than those in the non-severe group (Z=-4.39 and -1.96, P<0.05), and the number of CD3+ T lymphocyte cells, CD4+ T lymphocyte cells and CD8+ T lymphocyte cells in the severe group was lower than that in the non-severe group (Z=27.25, 20.60 and 17.36, P<0.05). Compared with the non-severe group, both lungs and the right lung lower lobe were more susceptible to be involved(χ2=9.71 and 23.61, P<0.05). Conclusions There are significant differences in underlying diseases, clinical symptoms, imaging manifestations and laboratory findings between severe and non-severe patients with COVID-19. Key words: 2019 novel coronavirus; COVID-19; Clinical features; Severe disease