Research Progresses on Synergism of Cry Toxins by Toxin-Binding Fragments

The Cry proteins produced by Bacillus thuringiensis(Bt) are the most widely used biopesticides effective against a range of crop pests.To exert its insecticidal activities and delay the evolution of resistance,synergism of Cry toxins by toxin-binding fragments were widely studied.As one of strategies of Bt resistance management, application of synergistic polypeptides can delay the evolution of Bt resistance.Here,we reviewed studies on synergism of Cry toxins by toxin-binding fragments and discussed the possible synergistic mechanisms.