Low 1-year cyclosporine microemulsion doses are associated with better 5-year renal graft function : An insight from MOST, a multinational observational study

Abstract Background In earlier registry analyses, cyclosporine at doses of Results Glomerular filtration rate (GFR) at year 1 was 63 ± 20 mL/min and 59 ± 22 mL/min at year 5. The multivariate analysis including year 1 CsA-ME dose as factor and GFR at 1 year as covariate revealed the most significant factors affecting GFR at year 5 were 1-year GFR, donor age > 60 years, and CsA-ME dose at 1 year. Risk factors associated with reduction in 5-year GFR ( 60 years, delayed graft function, cadaveric donor, previous graft, and acute rejection. CsA-ME dose Conclusions Compared to higher doses, CsA-ME