Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

Hong Ren,Kevin M. Maloney,Kallol Basu,Michael J. Di Maso,Guy R. Humphrey,Feng Peng,Richard Desmond,Douglas A. L. Otte,Embarek Alwedi,Wenjun Liu,Si-Wei Zhang,Siqing Song,Rebecca A. Arvary,Michael A. Zompa,Dan Lehnherr,Gary E. Martin,Hsieh Yao D. Chang,Anne E. Mohan,Francisco J. Guzman,Lisa Jellett,Alfred Y. Lee,Glenn Spencer,Elizabeth Fisher,John R. Naber,Hong Gao,Sachin Lohani,Rebecca T. Ruck,Louis-Charles Campeau

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

2020

A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...

Keywords:

P2X3 Receptor
Green chemistry
Process engineering
Engineering
Flow chemistry
sustainable manufacturing

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