New crystal of rivaroxaban and preparation method thereof
2016
The invention discloses a new crystal of rivaroxaban and a preparation method thereof. The new crystal of rivaroxaban is crystal SMN-F, X-ray powder diffraction spectrum of which has diffraction peaks when a diffraction angle 2theta is 3.7+/-0.2, 7.3+/-0.2, 14.5+/-0.2, 21.8+/-0.2, 29.2+/-0.2, 31.9+/-0.2 and 33.5+/-0.2. The preparation method of the rivaroxaban SMN-F crystal provided by the invention has the advantages of simple process, short time, and suitability for technological production, etc. At the same time, the rivaroxaban SMN-F crystal prepared by the method provided by the invention has the advantages of high purity, fast dissolution rate and good solubility, etc.
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