Correlation between pre-operative diagnosis and final pathological diagnosis of endometrial malignancies; impact on primary surgical treatment.

Abstract Objectives to compare the accuracy of preoperative and postoperative endometrial sampling obtained by dilatation and curettage (DC for endometrioid adenocarcinoma grade 1, they were 40.7% by DC for endometrioid adenocarcinoma grades 2 and 3, they were 83.7% and 84.6% by DC hysteroscopy showed 100% specificity, while Pipelle was the least accurate method. Finally, 61.4% of the patients received adequate surgical treatment. Conclusion There were excellent concordance rates between initial biopsy and postoperative pathology in diagnosis of high grade endometrioid and other endometrial malignancies compared to endometrial hyperplasia and low grade endometrioid adenocarcinoma. Patients diagnosed initially with atrophic endometrium or hyperplasia warranted more surveillance before their surgical treatment. It is crucial to develop protocols for increasing accuracy of endometrial sampling such as performing molecular studies for preoperative pathology.