Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents

Abstract A new series of antituberculosis agents 6 – 9 was designed, synthesized and evaluated for antituberculosis activity against Mycobacterium tuberculosis H 37 Rv and clinical isolates in an agar dilution method. Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H 37 Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis .