肝癌患者中 microRNA－378与 FOXO1基因表达的相关关系研究

Objective To study the expressions of miR-378 and FOXO1 in hepatocellular carcinoma ( HCC) and the correlation of the expressions between miR-378 and FOXO1 genes.Methods Matched normal and cancerous tissues from 8 patients with HCC were examined for miR-378 and FOXO1 expressions using real-time quantitative PCR.Independent-Samples T test was used to test the significance of the means of the expressions of miR-378 and FOXO1 between normal and cancerous tissues .The correlation of the expressions between miR-378 and FOXO1 in cancerous tissues was detected by bivariate correlation analysis .Results The expressions of miR-378 and FOXO1 in HCC cancerous tissues were both significantly lower than those in adjacent tissues ( P=0.0106 and P=0.000623 ) . The expression of miR-378 was positively correlated with that of FOXO 1 ( r=0.541 , P=0.031 ) in cancerous tis-sues.Conclusion The expressions of miR-378 and FOXO1 in HCC tissues are significantly lower than those of the adjacent tissues .The abnormal expressions of miR-378 and FOXO1 and their interaction network may play a vital role in HCC development .